Neurodevelopmental defects in a tauopathy model are affected by the microtubule stabilizer PTRN-1

Is decreased microtubule stability a key mechanism for tauopathies? Do Tau mutations cause developmental defects? Here, we show disease-associated Tau mutations induce developmental defects. Further, we test the effects of modulating microtubule stability through genetic deletion of the key stability regulator, ptrn-1